Granulation
Granulation
What Is Granulation
Granulation is a critical size-enlargement process in pharmaceutical manufacturing, where fine powder particles are bound together to form larger, free-flowing aggregates called granules. This process is fundamental to producing tablets and capsules that meet stringent standards for uniformity, compressibility, and bioavailability.
In pharmaceutical production, raw API powders often have poor flow characteristics, inconsistent particle size, and low compressibility, all of which can compromise the quality and efficacy of the final dosage form. Granulation addresses these challenges by transforming those powders into stable, uniform granules that can be reliably compressed into tablets or filled into capsules with consistent weight and drug content.
As a trusted pharmaceutical granulation equipment manufacturer, F Plus Healthcare designs granulation systems built for repeatable performance, contained operation, and full cGMP compliance, from early feasibility batches right through to commercial-scale production.
Your Complete Granulation Line Starts Here.
Integrated equipment, engineered for consistent output.
Eight equipment families designed to support every stage of the granulation process, with precision, containment, and control at every step.
Integrated Granulation Line
F Plus’s Integrated Granulation Line brings the entire granulation workflow, mixing, wet massing, drying, milling, and material transfer, into a single, fully contained system. Designed as a true plug-and-play pharmaceutical granulation machine, it supports simultaneous multi-stage processing with a small footprint, toolless changeovers, and isolator compatibility for high-containment environments. Ideal for feasibility batches through to full commercial production, with built-in data integrity and global regulatory compliance.
Sifter
The F Plus Sifter ensures accurate particle size classification before and after granulation, removing oversize particles and agglomerates that can compromise downstream processing. Designed for easy integration into your granulation line, it delivers consistent sieving performance with a contained, easy-to-clean build suited for cGMP pharmaceutical environments.
Mixer (High Shear Mixer Granulator)
The F Plus high shear mixer granulator delivers rapid, intensive blending of API and excipients, producing dense, uniform wet granules with controlled particle size distribution. Engineered for repeatable granule quality batch after batch, this pharmaceutical granulation machine is built for contained operation, quick changeovers, and full compliance with cGMP manufacturing standards.
FBE – Fluid Bed Equipment
The F Plus Fluid Bed Equipment range, developed by an experienced fluid bed dryer manufacturer, delivers precise drying, granulation, and coating within a single contained unit. Hot air is passed through the fluidised product bed, removing moisture uniformly and producing free-flowing granules with controlled density and residual moisture levels, critical for tablet compression performance and product stability.
Blender
The F Plus Blender ensures thorough, uniform mixing of dried granules with lubricants and other excipients prior to compression or encapsulation. Designed for gentle, low-shear blending that preserves granule integrity, it handles varying batch sizes with consistent output and is built to fit seamlessly into your broader granulation equipment line.
Tray Dryers
F Plus Tray Dryers offer a reliable and cost-effective solution for drying wet granules across a range of batch sizes. With uniform air circulation and precise temperature control, they deliver consistent drying performance without compromising granule structure, suitable for heat-sensitive formulations and multi-product facilities.
Mills
The F Plus Mills are engineered for precise milling and sizing of dried granules, ensuring the particle size distribution required for optimal tablet compression or capsule filling. Available in multiple configurations to match your throughput and formulation requirements, they integrate cleanly into any cGMP pharmaceutical granulation equipment setup.
Bin Washing System
The F Plus Bin Washing System automates the cleaning of IBCs and process bins used across the granulation line, delivering validated, reproducible cleaning results with minimal manual intervention. Designed to reduce contamination risk and downtime between product changeovers, it supports multi-product facilities operating under strict cGMP and containment requirements.
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Frequently Asked Questions
Questions before you begin?
Start with the essentials, then speak with our team about your formulation, capacity and facility requirements.
Granulation is a size-enlargement process that converts fine powders into more uniform, free-flowing granules. It can improve flow, compressibility, content uniformity, handling, and downstream tablet or capsule production.
F Plus supplies integrated granulation lines, sifters, high shear mixer granulators, fluid bed equipment, blenders, tray dryers, mills, and automated bin washing systems.
Selection depends on the formulation, wet or dry process, batch size, moisture target, particle-size requirement, containment level, cleaning strategy, available space, and planned production output.
A high shear mixer granulator rapidly blends API and excipients and forms controlled wet granules using an impeller and chopper. This supports repeatable granule density and particle-size distribution.
A fluid bed processor can support drying, granulation, and coating by passing controlled, filtered air through a fluidised product bed. It is commonly used when uniform heat and mass transfer are required.
Yes. Equipment can be configured for contained transfer, easy cleaning, data integrity, and cGMP-focused operation according to the product hazard, process, facility, and target market.
